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© Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition

Publications

2022

  1. Muraoka S, Hirano M, Isoyama J, Ishida M, Tomonaga T, Adachi J.* Automated Proteomics Sample Preparation of Phosphatidylserine-Positive Extracellular Vesicles from Human Body Fluids. ACS Omega. 7(45):41472-41479. 2022.  DOI: 10.1021/acsomega.2c05244
  2. Adachi J*, Kakudo A, Takada Y, Isoyama J, Ikemoto N, Abe Y, Narumi R, Muraoka S, Gunji D, Hara Y, Katayama R, Tomonaga T. Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis. Life Sci Alliance. 5(8):e202101202. 2022.DOI: 10.26508/lsa.202101202
  3. Kasahara K, Narumi R, Nagayama S, Masuda K, Esaki T, Obama K, Tomonaga T, Sakai Y, Shimizu Y, Adachi J.* A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer. Cancer Med. 12(6):7616-7626. 2022. DOI: 10.1002/cam4.5442
  4. Choi Y, Takasugi M, Takemura K, Yoshida Y, Kamiya T, Adachi J, Tsuruta D, Ohtani N. Characterization of Transcriptomic and Proteomic Changes in the Skin after Chronic Fluocinolone Acetonide Treatment. Biomolecules. 12(12):1822. 2022. DOI: 10.3390/biom12121822
  5. Kanao E, Wada S, Nishida H, Kubo T, Tanigawa T, Imami K, Shimoda A, Umezaki K, Sasaki Y, Akiyoshi K, Adachi J, Otsuka K, Ishihama Y. Classification of Extracellular Vesicles Based on Surface Glycan Structures by Spongy-like Separation Media. Anal Chem. 94(51):18025-18033, 2022.DOI: 10.1021/acs.analchem.2c04391
  6. Kawasaki T, Takeda Y, Edahiro R, Shirai Y, Nogami-Itoh M, Matsuki T, Kida H, Enomoto T, Hara R, Noda Y, Adachi Y, Niitsu T, Amiya S, Yamaguchi Y, Murakami T, Kato Y, Morita T, Yoshimura H, Yamamoto M, Nakatsubo D, Miyake K, Shiroyama T, Hirata H, Adachi J, Okada Y, Kumanogoh A. Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19. Inflamm Regen. 42(1):53. 2022. DOI: 10.1186/s41232-022-00243-5
  7. Kajiwara K, Chen PK, Abe Y, Okuda S, Kon S, Adachi J, Tomonaga T, Fujita Y, Okada M.* Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition. Curr Biol. 32(16):3460-3476.e6. 2022.DOI: 10.1016/j.cub.2022.06.038
  8. Shirai K, Hikita H, Sakane S, Narumi R, Adachi J, Doi A, Tanaka S, Tahata Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Mita E, Tomonaga T, Takehara T.* Serum amyloid P component and pro-platelet basic protein in extracellular vesicles or serum are novel markers of liver fibrosis in chronic hepatitis C patients. PLoS One. 17(7):e0271020. 2022.DOI: 10.1371/journal.pone.0271020
  9. Tomiyama E, Fujita K, Matsuzaki K, Narumi R, Yamamoto A, Uemura T, Yamamichi G, Koh Y, Matsushita M, Hayashi Y, Hashimoto M, Banno E, Kato T, Hatano K, Kawashima A, Uemura M, Ukekawa R, Takao T, Takada S, Uemura H, Adachi J, Tomonaga T, Nonomura N.* EphA2 on urinary extracellular vesicles as a novel biomarker for bladder cancer diagnosis and its effect on the invasiveness of bladder cancer. Br J Cancer. 127(7):1312-1323. 2022.DOI: 10.1038/s41416-022-01860-0
  10. Hirano H, Abe Y, Nojima Y, Aoki M, Shoji H, Isoyama J, Honda K, Boku N, Mizuguchi K, Tomonaga T*, Adachi J*. Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer. Sci Rep 12(1):4419. 2022.DOI: 10.1038/s41598-022-08430-7
  11. Muraoka S, Hirano M, Isoyama J, Nagayama S, Tomonaga T, Adachi J*. Comprehensive proteomic profiling of plasma and serum phosphatidylserine-positive extracellular vesicles reveals tissue-specific proteins. iScience. 25(4):104012. 2022.DOI: 10.1016/j.isci.2022.104012
  12. Nagatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, Ohno H, Tiwari P, Morimoto S, Node E, Adachi J, Abe Y, Isoyama J, Sawane K, Honda T, Inoue A, Uwamizu A, Matsuzaka T, Miyamoto Y, Hirata SI, Saika A, Shibata Y, Hosomi K, Matsunaga A, Shimano H, Arita M, Aoki J, Oka M, Matsutani A, Tomonaga T, Kabashima K, Miyachi M, Yasutomi Y, Ogawa J, Kunisawa J*. Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Mucosal Immunol. 15(2):289-300. 2022.DOI: 10.1038/s41385-021-00477-5
  13. Futami Y, Takeda Y, Koba T, Narumi R, Nojima Y, Ito M, Nakayama M, Ishida M, Yoshimura H, Naito Y, Fukushima K, Takimoto T, Edahiro R, Matsuki T, Nojima S, Hirata H, Koyama S, Iwahori K, Nagatomo I, Shirai Y, Suga Y, Satoh S, Futami S, Miyake K, Shiroyama T, Inoue Y, Adachi J, Tomonaga T, Ueda K, Kumanogoh A*. CD14 and lipopolysaccharide-binding protein as novel biomarkers for sarcoidosis by proteomics of serum extracellular vesicles. Int Immunol. dxac009. 2022.DOI: 10.1093/intimm/dxac009
  14. Shimizu Y, Okada K, Adachi J, Abe Y, Narumi R, Uchibori K, Yanagitani N, Koike S, Takagi S, Nishio M, Fujita N, Katayama R*. GSK3 inhibition circumvents and overcomes acquired lorlatinib resistance in ALK-rearranged non-small-cell lung cancer. NPJ Precis Oncol. 6(1):16. 2022.DOI: 10.1038/s41698-022-00260-0