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© Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition

研究業績Achievements

2024年

  1. Gunji D, Abe Y, Muraoka S, Narumi R, Isoyama J, Ikemoto N, Ishida M, Shinkura A, Tomonaga T, Nagayama S, Takahashi Y, Fukunaga Y, Sakai Y, Obama K, Adachi J*. Longitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases. Cell Rep. 43(12):115061. DOI: 10.1016/j.celrep.2024.115061. 
  2. Shoji H, Hirano H, Nojima Y, Gunji D, Shinkura A, Muraoka S, Abe Y, Narumi R, Nagao C, Aoki M, Obama K, Honda K, Mizuguchi K, Tomonaga T, Saito Y,  Yoshikawa T, Kato K, Boku N, Adachi J*. Phosphoproteomic subtyping of gastric cancer reveals dynamic transformation with chemotherapy and guides targeted cancer treatment. Cell rep. 43(10):114774. 2024. DOI: 10.1016/j.celrep.2024.114774 
  3. Fujimura T, Furugaki K, Mizuta H, Muraoka S, Nishio M, Adachi J, Uchibori K, Miyauchi E, Hayashi H, Katayama R, Yoshiura S. Targeting ErbB and tankyrase1/2 prevent the emergence of drug-tolerant persister cells in ALK-positive lung cancer. NPJ Precis Oncol. 8(1):264. 2024. DOI: 10.1038/s41698-024-00757-w.
  4. Shinkura A, Adachi J*. Protocol for phosphoproteomic analysis. J. Proteome Data and Methods. 6, 14. 2024. DOI:https://doi.org/10.14889/jpdm.2024.0014
  5. Abe Y, Hirano H, Shoji H, Boku N, Tomonaga T, Adachi J.* Data for Comprehensive characterization of the phosphoproteome of gastric cancer from endoscopic biopsy specimens. J. Proteome Data and Methods. 6, 24. 2024. DOI:https://doi.org/10.14889/jpdm.2024.
  6. Hosomi K, Hatanaka N, Hinenoya A, Adachi J, Tojima Y, Furuta M, Uchiyama K, Morita M, Nagatake T, Saika A, Kawai S, Yoshii K, Kondo S, Yamasaki S, Kunisawa J. QcrC is a potential target for antibody therapy and vaccination to control Campylobacter jejuni infection by suppressing its energy metabolism. Front Microbiol. 15:1415893. 2024. DOI:10.3389/fmicb.2024.1415893.
  7. Enomoto T, Shirai Y, Takeda Y, Edahiro R, Shichino S, Nakayama M, Takahashi-Itoh M, Noda Y, Adachi Y, Kawasaki T, Koba T,Futami Y, Yaga M, Hosono Y,Yoshimura H, Amiya S, Hara R, Yamamoto M, Nakatsubo D, Suga Y,Naito M, Masuhiro K, Hirata H, Iwahori K, Nagatomo I, Miyake K, Koyama S, Fukushima K, Shiroyama T, Naito Y, Futami S, Natsume-Kitatani Y, Nojima S, Yanagawa M, Shintani Y, Nogami-Itoh M, Mizuguchi K, Adachi J, Tomonaga T, Inoue Y, Kumanogoh A. SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosis. JCI insight 9(11).  2024.  DOI: 10.1172/jci.insight.177937
  8. Sakane S, Hikita H, Shirai K, Sakamoto T, Narumi R, Adachi J, Kakita N, Yamada Y, Toyoda H, Takahashi H, Suda G, Kai M, Tahata Y, Sakamori R, Kumazaki S, Fukumoto K, Myojin Y, Kodama T, Tatsumi T, Tomonaga T, Sakamoto N, Morii E, Takehara T. Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD. Hepatol Commun. 8(6):e0448. 2024. DOI: 10.1097/HC9.0000000000000448
  9. Muraoka S, Adachi J*. Systematic identification of kinase-substrates relationship by integrated phosphoproteome and interactome analysis. Methods Mol Biol., Proteomics for Drug Discovery. 2024. DOI:10.1007/978-1-0716-3922-1_2 .
  10. Tozuka T, Noro R, Yoshida K, Takahashi S, Hirao M, Matsuda M, Kato Y, Nakamichi S, Takeuchi S, Matsumoto M, Miyanaga A, Kunugi S, Honda K, Adachi J, Seike M. Phosphoproteomic analysis identified mutual phosphorylation of FAK and Src as a mechanism of osimertinib resistance in EGFR-mutant lung cancer. JTO Clin Res Rep. 5:10068. 2024. DOI:https://doi.org/10.1016/j.jtocrr. 2024.100668
  11. Yoshimura H, Takeda Y, Shirai Y, Yamamoto M, Nakatsubo D, Amiya S, Enomoto T, Hara R, Adachi Y, Edahiro R, Yaga M, Masuhiro K, Koba T, Itoh-Takahashi M, Nakayama M, Takata S, Hosono Y, Obata S, Nishide M, Hata A, Yanagawa M, Namba S, Iwata M, Hamano M, Hirata H, Koyama S, Iwahori K, Nagatomo I, Suga Y, Miyake K, Shiroyama T, Fukushima K, Futami S, Naito Y, Kawasaki T, Mizuguchi K, Kawashima Y, Yamanishi Y, Adachi J, Nogami-Itoh M, Ueki S, Kumanogoh A. Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology. Journal of Allergy and Clinical Immunology. 153(5) 1268-1281. 2024. DOI: 10.1016/j.jaci.2023.12.030
  12. Tomoto M, Mineharu Y, Sato N, Tamada Y, Nogami-Itoh M, Kuroda M, Adachi J, Takeda Y, Mizuguchi K, Kumanogoh A, Natsume-Kitatani Y, Okuno Y. Idiopathic pulmonary fibrosis-specific Bayesian network integrating extracellular vesicle proteome and clinical information. Sci Rep. 14(1):1315. 2024. DOI: 10.1038/s41598-023-50905-